US Flag logoAn official website of the United States government
Pediatric Cancer Genome Project
St. Jude Cloud
Data Resource:  St. Jude Cloud
Point of Contact:  
Clay McLeod ; Jinghui Zhang,  
Project

About This Dataset
In 2010, St. Jude Children's Research Hospital and Washington University School of Medicine launched a $65 million, three-year project to define the genomic landscape of pediatric cancer, including some of the least understood and most challenging cancers. The project goal was to sequence the complete normal and cancer genomes of 600 pediatric cancer patients. The St. Jude-Washington University Pediatric Cancer Genome Project became an ambitious effort to discover the origins of pediatric cancer and seek new treatments. The project ultimately sequenced the complete and normal genomes of about 800 pediatric cancer patients. It included whole exome and whole transcriptome sequencing of an additional 1,200 patients, which included more than 20 different cancers.
Core Data Elements
Number of Cases
1,630
Case Sex
Female (542); Male (660); Not Reported (428)
Case Age At Diagnosis
0 to 4 years (390); 5 to 9 years (253); 10 to 14 years (202); 15 to 19 years (158); 20 to 24 years (17); 25 to 29 years (1); 30 to 34 years (1); Pediatric and Young Adult (<40 years) (608)
Case Race
Asian (13); Black or African American (149); More Than One Race (2); Native Hawaiian or Other Pacific Islander (1); White (577); Not Reported (888)
Case Ethnicity
Hispanic or Latino (49); Not Hispanic or Latino (569); Not Reported (1,012)
Case Disease Diagnosis
Acute Megakaryoblastic leukemia (20); Adrenocortical Tumor (39); AE (1); B-cell Acute Lymphoblastic Leukemia, E2A-PBX1 (51); B-cell Acute Lymphoblastic Leukemia, ERG (37); B-cell Acute Lymphoblastic Leukemia, ETV6-RUNX1 (53); B-cell Acute Lymphoblastic Leukemia, NOS (78); Choroid Plexus Carcinoma (4); Core Binding Factor Acute Myeloid Leukemia (75); Core Binding Factor Acute Myeloid Leukemia;AE (1); Core Binding Factor Acute Myeloid Leukemia;inv(16) (10); Ependymoma, NOS (61); Ewing's Sarcoma (19); HGG (2); High grade glioma (94); High grade glioma;DIPG (3); High grade neuroepithelial tumor (1); Hyperdiploid Acute Lymphoblastic Leukemia (69); Hypodiploid Acute Lymphoblastic Leukemia (35); Infantile Acute Lymphoblastic Leukemia (31); inv(16) (1); Lineage:B,Primary_subtype:B-other (4); Lineage:B,Primary_subtype:DUX4 (30); Lineage:B,Primary_subtype:DUX4,Secondary_subtype:ETV6-RUNX1-like (2); Lineage:B,Primary_subtype:ETV6-RUNX1-like (1); Lineage:B,Primary_subtype:ETV6-RUNX1-like,Secondary_subtype:iAMP21 (1); Lineage:B,Primary_subtype:Hyperdiploid (5); Lineage:B,Primary_subtype:Hyperdiploid,Secondary_subtype:Ph-like_non CRLF2 (1); Lineage:B,Primary_subtype:iAMP21 (6); Lineage:B,Primary_subtype:KMT2A-like (1); Lineage:B,Primary_subtype:MEF2D (4); Lineage:B,Primary_subtype:Near haploid,Secondary_subtype:Ph-like_non CRLF2 (1); Lineage:B,Primary_subtype:PAX5 P80R (2); Lineage:B,Primary_subtype:PAX5alt (5); Lineage:B,Primary_subtype:PAX5alt,Secondary_subtype:Ph-like_non CRLF2 (1); Lineage:B,Primary_subtype:Ph (11); Lineage:B,Primary_subtype:Ph,Secondary_subtype:Hyperdiploid (3); Lineage:B,Primary_subtype:Ph-like_CRLF2,Secondary_subtype:iAMP21 (2); Lineage:B,Primary_subtype:Ph-like_non CRLF2 (20); Lineage:B,Primary_subtype:Ph-like_non CRLF2,Secondary_subtype:iAMP21 (3); Lineage:B,Primary_subtype:ZNF384 (1); Lineage:B,Primary_subtype:ZNF384-like (1); Lineage:T,Primary_subtype:T-other (1); Low grade glioma (38); Medulloblastoma (37); Melanoma, NOS (5); MLL Rearranged Leukemia (20); Neuroblastoma (100); Osteosarcoma, NOS (40); Ph+ Acute Lymphoblastic Leukemia (37); Retinoblastoma (1); Retinoblastoma, NOS (14); Rhabdomyosarcoma, NOS (41); T-cell Acute Lymphoblastic Leukemia (29); Not Reported (477)
Case Tumor Site
Not Reported (1,630)
Number of Samples
3,023
Sample Assay Method
RNA Sequencing (245); Whole Exome Sequencing (1,380); Whole Genome Sequencing (1,398)
Sample Is Xenograft
Yes (10)
Additional Data Elements
DATA REPOSITORY
Grant Information
P30CA021765
Cancer Center Support Grant
PROGRAM ID
PAR-17-095
Published In
https://doi.org/10.1038/ng.2287
SAMPLE TYPE
Autopsy (57);  
Cell Line (19);  
Diagnosis (1,514);  
Germline (1,293);  
Metastasis (28);  
Relapse (102);  
Charts
Male (660); Female (542); Not Reported (428)
660Male